Repeat dosing is not supported by clinical data and is not recommended. One type of factor IX product, which is also called prothrombin complex concentrate (PCC), may contain clinically useful quantities of vitamin K–dependent clotting factors II, VII, and X {06} {10} {15} {16} {25} {27} {35} in addition to factor IX. Prothrombin complex concentrate, also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. It may also be used in those with not enough of these factors due to other reasons such as warfarin therapy.

Dosing guidelines. PCC is a sterile, lyophilized concentrate of factors II, VII, IX, and X and protein C and S. Prior to development of FIX concentrates, PCC with low amounts of FVII (3-factor PCC) was used to treat hemophilia B. The 4-factor prothrombin complex concentrate (4F-PCC), which contains the human coagulation factors II, VII, IX and X together with the endogenous inhibitor proteins S and C, is indicated for the urgent reversal of acquired coagulation factor deficiency induced by VKA (e.g. BACKGROUND: Prothrombin complex concentrate (PCC) has recently emerged as an effective alternative to fresh frozen plasma (FFP) in treating excessive perioperative bleeding. Some versions also contain factor VII.
O FDA has approved prothrombin complex concentrate (PCC), human (Kcentra—CSL Behring), for the urgent reversal of anticoagulation in adults who develop acute bleeding from therapy with warfarin and other vitamin K antagonist (VKA) anticoagulants. warfarin or coumarin) therapy in adult patients with acute major bleeding. Autoplex versus Proplex: a controlled, double-blind study of effectiveness in acute hemarthroses in hemophiliacs with inhibitors to factor VIII.
It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available.

Lusher JM, Blatt PM, Penner JA, et al. Administer vitamin K concurrently to maintain vitamin K-dependent clotting factor levels once the effects of prothrombin complex concentrate have diminished. This systematic review and meta-analysis evaluated the safety and efficacy of PCC administration as first-line treatment for coagulopathy after adult cardiac surgery. The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII.N Engl J Med 1981; 305: 717-21. Prothrombin Complex Concentrate. Common side effects include allergic reactions, headache, vomiting, and sleepiness. It is given by slow injection into a vein.


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